ASUS ROG STRIX X399-E GAMING AMD X399 ATX Motherboard for Ryzen Threadripper with DDR4, PCIe 3.0, Wi-Fi, Bluetooth 4.2 and RGB Aura Sync

The ASUS ROG STRIX X399-E GAMING Motherboard has been engineered for high-performance desktop computers powered by 1st and 2nd Generation AMD Ryzen Threadripper processors. Built around the AMD X399 chipset and AMD SocketTR4, this Extended ATX motherboard is designed to support demanding gaming configurations, professional workloads, content creation, and advanced multitasking. Up to 128GB of DDR4 memory can be installed across eight DIMM slots, with supported overclocked memory speeds of up to 3600MHz. Exceptional processing performance, extensive expansion capabilities, and advanced overclocking technologies are provided for enthusiasts seeking a powerful and customizable PC platform.

Advanced graphics and storage configurations are supported through four PCIe 3.0 x16 slots, NVIDIA SLI technology, and AMD CrossFireX multi-GPU support. High-speed storage connectivity is provided through dual M.2 sockets, a U.2 port, and six SATA 6Gb/s connectors, allowing fast SSD installations and flexible storage arrangements. M.2 and U.2 connectivity with transfer speeds of up to 32Gb/s is supported, while RAID 0, RAID 1, and RAID 10 configurations are also available. Extensive USB connectivity, including USB 3.1 Gen 2 Type-A and Type-C ports, is provided for compatible peripherals and external devices.

An immersive gaming experience is supported by ROG SupremeFX 8-channel HD audio, Sonic Studio III, and Sonic Radar III technologies. High-quality audio components, dedicated PCB layers, audio shielding, and premium Japanese capacitors are incorporated to provide clear and detailed sound. Wireless connectivity is also included through dual-band Wi-Fi 802.11ac and Bluetooth 4.2, while Intel Gigabit LAN with ROG GameFirst IV is provided for optimized network performance. Additionally, ASUS Aura Sync RGB lighting, customizable headers, and synchronized lighting effects are supported, allowing the system's appearance to be personalized.

For advanced system customization, ASUS PRO Clock Technology, 5-Way Optimization, DIGI+ VRM, Fan Xpert 4, and comprehensive UEFI BIOS controls are included. Convenient maintenance and installation features such as USB BIOS FlashBack, Q-Code, Q-LED, Q-Shield, and Q-Slot are also provided. With its premium ROG design, extensive connectivity, advanced cooling support, and powerful overclocking capabilities, the ASUS ROG STRIX X399-E GAMING motherboard is suitable for high-end gaming PCs and workstation-style desktop builds.

Key Features

• AMD X399 Chipset and SocketTR4: Support is provided for 1st and 2nd Generation AMD Ryzen Threadripper processors, delivering a powerful foundation for demanding desktop computing and gaming systems.

• Eight DDR4 Memory Slots: Up to 128GB of ECC or non-ECC unbuffered DDR4 memory is supported, with overclocked speeds of up to 3600MHz for enhanced multitasking and system performance.

• Advanced Multi-GPU Support: NVIDIA Quad-GPU SLI, 3-Way SLI, 2-Way SLI, and AMD Quad-GPU CrossFireX technologies are supported for advanced graphics configurations.

• Four PCIe 3.0 x16 Slots: Multiple high-speed expansion slots are provided for compatible graphics cards and other PCIe devices.

• Dual M.2 and U.2 Storage Connectivity: High-speed SSD storage is supported through two M.2 sockets and one U.2 port, with transfer speeds of up to 32Gb/s.

• Six SATA 6Gb/s Connectors: Additional storage devices can be connected, with RAID 0, RAID 1, and RAID 10 configurations supported.

• Intel Gigabit Ethernet and GameFirst IV: Network connectivity is provided through the Intel I211-AT LAN controller, with GameFirst IV technology included for network traffic optimization.

• Wi-Fi 802.11ac and Bluetooth 4.2: Wireless networking and Bluetooth connectivity are integrated for compatible wireless peripherals and network connections.

• ROG SupremeFX S1220A Audio: High-definition 8-channel audio is supported through advanced shielding, premium capacitors, dedicated audio PCB layers, and an integrated amplifier.

• Sonic Studio III and Sonic Radar III: Audio customization and in-game sound visualization tools are provided to enhance the gaming experience.

• USB 3.1 Gen 2 Type-A and Type-C: High-speed USB connectivity is provided for compatible external devices and peripherals.

• ASUS Aura Sync RGB Lighting: Customizable RGB lighting effects are supported through onboard Aura headers and synchronization with compatible ASUS ROG components.

• ASUS PRO Clock Technology: Advanced BCLK control is provided to support extreme overclocking configurations.

• 5-Way Optimization: TPU, EPU, DIGI+ VRM, Fan Xpert 4, and Turbo App technologies are combined to simplify system tuning and performance management.

• Advanced Cooling Connectivity: Multiple fan headers, AIO pump connectivity, W_PUMP+ support, and thermal sensor connections are provided for customized cooling configurations.

• USB BIOS FlashBack: BIOS updating functionality is provided through a dedicated button, simplifying firmware maintenance.

• ASUS Q-Design: Installation and troubleshooting are simplified through Q-Shield, Q-Code, Q-LED, Q-Slot, Q-DIMM, and Q-Connector features.

• ROG Exclusive Software: ROG RAMCache II, ROG CloneDrive, ROG CPU-Z, GameFirst IV, and Overwolf are supported for additional system functionality.

• Extended ATX Design: A spacious 30.5 x 26.9 cm motherboard layout is provided for compatible Extended ATX computer cases.

Specifications

Model

• Product Name: ASUS ROG STRIX X399-E GAMING

• Motherboard Form Factor: Extended ATX

• Dimensions: 12 x 10.6 inches (30.5 x 26.9 cm)

CPU

• CPU Socket: AMD SocketTR4

• Processor Support: 1st and 2nd Generation AMD Ryzen Threadripper Processors

• CPU compatibility information: Refer to the ASUS CPU support list.

Chipset

• AMD X399

Memory

• 8 x DIMM slots

• Maximum Memory Capacity: 128GB

• Memory Type: DDR4

• Memory Frequencies:

  • 3600MHz (O.C.)

  • 3466MHz (O.C.)

  • 3333MHz (O.C.)

  • 3200MHz (O.C.)

  • 3000MHz (O.C.)

  • 2800MHz (O.C.)

  • 2666MHz

  • 2400MHz

  • 2133MHz

• Memory Support: ECC and non-ECC unbuffered memory

• Memory compatibility information: Refer to the ASUS Memory QVL (Qualified Vendors List).

Multi-GPU Support

AMD Ryzen Threadripper Processors:

• NVIDIA Quad-GPU SLI Technology

• NVIDIA 3-Way SLI Technology

• NVIDIA 2-Way SLI Technology

• AMD Quad-GPU CrossFireX Technology

AMD Ryzen 2nd Generation / 1st Generation Processors:

• AMD 3-Way CrossFireX Technology

• AMD 2-Way CrossFireX Technology

Expansion Slots

• 4 x PCIe 3.0 x16 slots:

  • Single: x16

  • Dual: x16/x16

  • Triple: x16/x16/x8

• 1 x PCIe 2.0 x4 slot (maximum x4 mode)

• AMD X399 Chipset:

  • 1 x PCIe 2.0 x1 slot

Storage

• 2 x M.2 Socket 3 with M Key

• M.2 Supported Sizes: 2242, 2260, 2280, 22110 (first socket)

• M.2 Supported Sizes: 2242, 2260, 2280 (second socket)

• M.2 Interface: SATA and PCIe 3.0 x4

• 1 x U.2 port

• 6 x SATA 6Gb/s ports

• RAID Support: RAID 0, RAID 1, RAID 10

LAN

• Intel I211-AT Gigabit Ethernet

• ROG GameFirst IV

• Anti-surge LANGuard

Wireless Data Network

• Wi-Fi 802.11 a/b/g/n/ac

Bluetooth

• Bluetooth 4.2

Audio

• ROG SupremeFX 8-Channel High Definition Audio CODEC S1220A

• 120dB SNR line-out (rear)

• 113dB SNR recording input (line-in)

• Sonic Studio III

• Sonic Radar III

• Impedance sensing for front and rear headphone outputs

• Integrated audio amplifier for headphones and speakers

• Jack detection

• Multi-streaming

• Front panel jack retasking

Audio Features:

• SupremeFX Shielding Technology

• Optical S/PDIF output on the rear panel

• Audio shielding for analog/digital separation and reduced interference

• Dedicated PCB layers for left and right audio channels

• Premium Japanese-made audio capacitors

• De-pop circuit to reduce startup popping noise

• EMI protection cover for amplifier noise protection

USB Ports

Rear I/O:

• 8 x USB 3.1 Gen 1 Type-A ports

Mid-board:

• 1 x USB 3.1 Gen 2 port

AMD Ryzen Threadripper Processors:

• 4 x USB 3.1 Gen 1 ports (mid-board)

AMD X399 Chipset:

• ASMedia USB 3.1 Gen 2 controller

• 2 x USB 3.1 Gen 2 ports (Type-A + USB Type-C)

• 4 x USB 2.0 ports (mid-board)

ROG Exclusive Features

• ROG RAMCache II

• ROG CloneDrive

• GameFirst IV

• ROG CPU-Z

• Overwolf

Special Features

• ASUS USB BIOS FlashBack

• USB BIOS FlashBack

• Onboard Power Button

OC Design – ASUS PRO Clock Technology:

• Full BCLK range for extreme overclocking performance

• Stylish heat-pipe cooling solution

ASUS Dual Intelligent Processors 5-Way Optimization:

• TPU

• EPU

• DIGI+ VRM

• Fan Xpert 4

• Turbo App

AURA:

• Aura Lighting Control

• Aura RGB Strip Headers

• Aura Lighting Effects Synchronization with compatible ASUS ROG devices

• Aura Addressable Strip Header

ASUS Exclusive Features:

• AI Suite 3

• Ai Charger

ASUS Quiet Thermal Solution:

• ASUS Fan Xpert 4

ASUS EZ DIY:

• ASUS EZ Flash 3

• ASUS UEFI BIOS EZ Mode

• Multi-language BIOS

ASUS Q-Design:

• ASUS Q-Shield

• ASUS Q-Code

• ASUS Q-LED (CPU, DRAM, VGA, Boot Device LED)

• ASUS Q-Slot

• ASUS Q-DIMM

• ASUS Q-Connector

Gaming Aesthetics:

• 3D printing friendly

• AURA RGB Lighting

Onboard Storage Technology:

• M.2 and U.2 connectivity

• Transfer speeds of up to 32Gb/s for M.2 and U.2

Back I/O Ports

• 1 x USB BIOS FlashBack Button

• 2 x USB 3.2 Gen 2 ports (Teal Blue): Type-A + USB Type-C

• 8 x USB 3.2 Gen 1 ports (Blue)

• 1 x ASUS 2x2 Wi-Fi 802.11 a/b/g/n/ac and Bluetooth 4.2 module

• 1 x LAN (RJ45) port

• 1 x Optical S/PDIF output

• 5 x Audio jacks

Internal I/O Ports

• 1 x Q-Code connector

• 1 x Aura Addressable Strip Header

• 1 x M.2 Socket 3 with M Key (2242/2260/2280/22110, SATA and PCIe 3.0 x4)

• 1 x USB 3.1 Gen 2 front panel connector

• 2 x Aura RGB Strip Headers

• 2 x USB 3.1 Gen 1 connectors (up to 5Gbps), supporting 4 additional USB 3.1 Gen 1 ports

• 2 x USB 2.0 connectors, supporting 4 additional USB 2.0 ports

• 1 x M.2 Socket 3 with M Key (2242/2260/2280, SATA and PCIe 3.0 x4)

• 6 x SATA 6Gb/s connectors

• 1 x M.2_FAN connector

• 1 x CPU Fan connector

• 1 x CPU OPT Fan connector

• 3 x Chassis Fan connectors

• 1 x AIO_PUMP connector

• 1 x W_PUMP+ connector

• 1 x 24-pin EATX Power connector

• 1 x 8-pin ATX 12V Power connector

• 1 x 4-pin ATX 12V Power connector

• 1 x Front Panel Audio connector (AAFP)

• 1 x System Panel connector

• 1 x 5-pin EXT_FAN (Extension Fan) connector

• 1 x Thermal Sensor connector

• 1 x Power-on button

• 1 x Clear CMOS jumper

Accessories

• 1 x Thermal sensor cable pack

• ROG Fan Label

• 1 x Cable tie pack

• 1 x 10-in-1 ROG cable label

• 1 x ROG Door Hanger

• ASUS Q-Shield

• 1 x Vertical M.2 bracket set

• 1 x SLI HB Bridge (2-WAY-M)

• User Manual

• 4 x SATA 6Gb/s cables

• 1 x M.2 Screw Package

• 1 x Supporting DVD

• 1 x Q-Connector

• 1 x Extension cable for Addressable LED

BIOS

• 128 Mb Flash ROM

• UEFI AMI BIOS

• PnP

• WfM 2.0

• SM BIOS 3.0

• ACPI 6.1

• Multi-language BIOS

• ASUS EZ Flash 3

• CrashFree BIOS 3

• F11 EZ Tuning Wizard

• F6 Qfan Control

• F3 My Favorites

• Last Modified Log

• F12 PrintScreen

• ASUS DRAM SPD (Serial Presence Detect) memory information

Manageability

• WfM 2.0

• DMI 3.0

• WOL by PME

• PXE

Operating System

• Windows 10 64-bit

Form Factor

• Extended ATX

• Dimensions: 12 x 10.6 inches (30.5 x 26.9 cm)

Conclusion

The ASUS ROG STRIX X399-E GAMING AMD X399 Motherboard is designed to deliver powerful computing capabilities, advanced gaming features, and extensive customization options for AMD Ryzen Threadripper desktop systems. With support for up to 128GB of DDR4 memory, multi-GPU graphics configurations, dual M.2 storage, U.2 connectivity, premium SupremeFX audio, Wi-Fi, Bluetooth, and Aura Sync RGB lighting, a comprehensive range of technologies is provided. Its advanced overclocking controls, extensive cooling connections, and convenient installation features make it a capable foundation for high-performance gaming computers and demanding workstation builds.